{"id":9216,"date":"2025-07-22T07:10:15","date_gmt":"2025-07-22T12:10:15","guid":{"rendered":"https:\/\/nanostherapeutics.com\/?p=9216"},"modified":"2025-07-23T18:30:25","modified_gmt":"2025-07-23T23:30:25","slug":"nanoscope-therapeutics-publishes-mechanism-of-action-details-for-proprietary-broadband-and-fast-multi-characteristic-opsin-technology","status":"publish","type":"post","link":"https:\/\/nanostherapeutics.com\/ar\/2025\/07\/22\/nanoscope-therapeutics-publishes-mechanism-of-action-details-for-proprietary-broadband-and-fast-multi-characteristic-opsin-technology\/","title":{"rendered":"\u0634\u0631\u0643\u0629 \u0646\u0627\u0646\u0648\u0633\u0643\u0648\u0628 \u062b\u064a\u0631\u0627\u0628\u064a\u0648\u062a\u0643\u0633 \u062a\u0646\u0634\u0631 \u062a\u0641\u0627\u0635\u064a\u0644 \u0622\u0644\u064a\u0629 \u0639\u0645\u0644 \u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u0623\u0648\u0628\u0633\u064a\u0646 \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0630\u0627\u062a \u0627\u0644\u0646\u0637\u0627\u0642 \u0627\u0644\u0639\u0631\u064a\u0636 \u0648\u0627\u0644\u0633\u0631\u064a\u0639 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0647\u0627"},"content":{"rendered":"
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New research paper highlights the unique structure and function of Nanoscope’s synthetic opsin, supporting its potential in vision restoration<\/h3>\n

\u062f\u0627\u0644\u0627\u0633<\/span><\/span>,\u00a022 \u064a\u0648\u0644\u064a\u0648 2025<\/span><\/span>\u00a0\u2014\u00a0\u0634\u0631\u0643\u0629 \u0646\u0627\u0646\u0648\u0633\u0643\u0648\u0628 \u0644\u0644\u0639\u0644\u0627\u062c\u0627\u062a<\/a>, \u0623\u0639\u0644\u0646\u062a \u0627\u0644\u064a\u0648\u0645 \u0634\u0631\u0643\u0629 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u064a\u0648\u064a\u0629\u060c \u0627\u0644\u0645\u0644\u062a\u0632\u0645\u0629 \u0628\u062a\u0637\u0648\u064a\u0631 \u0648\u062a\u0633\u0648\u064a\u0642 \u0639\u0644\u0627\u062c\u0627\u062a \u062c\u064a\u0646\u064a\u0629 \u0645\u0628\u062a\u0643\u0631\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0628\u0635\u0631 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0623\u0645\u0631\u0627\u0636 \u062a\u0646\u0643\u0633\u064a\u0629 \u0641\u064a \u0627\u0644\u0634\u0628\u0643\u064a\u0629\u060c \u0639\u0646 \u0646\u0634\u0631 \u0648\u0631\u0642\u0629 \u0628\u062d\u062b\u064a\u0629.\u00a0“<\/b>Topology and Mechanism of Broadband and Fast Multi-Characteristic Opsin (MCO) for Neuromodulation,”<\/b><\/a>\u00a0\u0641\u064a\u00a0\u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u062a\u0642\u062f\u0645\u0629\u060c,\u00a0<\/i>a peer-reviewed journal in Wiley’s prestigious\u00a0\u0645\u062a\u0642\u062f\u0645<\/i>\u00a0portfolio, known for showcasing high impact biomedical research. The paper details the biophysical characteristics of Nanoscope’s proprietary therapeutic approach, MCO, including its unique structure and function, which utilizes a combination of predictive protein modeling, molecular assays, and electrophysiology.<\/p>\n

The paper highlights Nanoscope’s groundbreaking research that supports the impact observed in patients treated with the company’s lead asset therapy, MCO-010. The findings lay the groundwork to further advance this technology to help individuals affected by a range of vision loss due to retinal degenerative diseases. Functional studies using electrical recordings demonstrated that MCO is activated by ambient light, exhibits fast on-off kinetics with high photosensitivity, and maintains a broad dynamic range across the visible spectrum, enabling robust, best-in-class light-activation of MCO-expressing cells.<\/p>\n

“The highly efficient mechanism of action of our ambient light-activatable MCO stems\u00a0from\u00a0its unique structure, which allows broadband light sensitivity combined with fast channel kinetics,” said\u00a0\u062f\u0643\u062a\u0648\u0631.\u00a0\u0633\u0627\u0645\u0627\u0631\u0646\u062f\u0631\u0627 \u0645\u0648\u0647\u0627\u0646\u062a\u064a<\/span>, President & Chief Scientific Officer<\/a>\u00a0at Nanoscope and lead author of the paper. “Based on this research and multiple clinical studies, a rolling submission was\u00a0\u062a\u0645 \u0645\u0624\u062e\u0631\u0627\u064b \u0627\u0644\u0628\u062f\u0621 \u0641\u064a \u062a\u0642\u062f\u064a\u0645 \u0637\u0644\u0628 \u062a\u0631\u062e\u064a\u0635 \u0644\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0625\u0644\u0649 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u0644\u0640 MCO-010<\/a>, with the potential to be the first gene-agnostic therapy to treat retinitis pigmentosa.”<\/p>\n

\u062a\u0645\u062b\u0644 \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0637\u0648\u0628\u0648\u0644\u0648\u062c\u064a\u0629 \u0648\u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0627\u0644\u0641\u0631\u064a\u062f\u0629 \u0644\u062a\u0646\u0634\u064a\u0637 \u0628\u0631\u0648\u062a\u064a\u0646 MCO \u0627\u0644\u0645\u062f\u0645\u062c \u0646\u062a\u0627\u0626\u062c \u062c\u062f\u064a\u062f\u0629 \u062a\u0631\u0628\u0637 \u0628\u064a\u0646 \u0641\u0639\u0627\u0644\u064a\u0629 \u0647\u0630\u0627 \u0627\u0644\u0623\u0648\u0628\u0633\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u0648\u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a\u060c \u0648\u0647\u0648 \u0623\u0645\u0631 \u0628\u0627\u0644\u063a \u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0644\u0644\u062a\u0639\u062f\u064a\u0644 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0630\u064a \u064a\u0647\u062f\u0641 \u0625\u0644\u0649 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0627\u0644\u0631\u0624\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0623\u0645\u0631\u0627\u0636 \u062a\u0646\u0643\u0633\u064a\u0629 \u0641\u064a \u0627\u0644\u0634\u0628\u0643\u064a\u0629.<\/p>\n

\u062f\u0643\u062a\u0648\u0631.\u00a0\u0623\u064a\u0648\u0646 \u0641\u0627\u064a\u0646<\/span>, \u0623\u0633\u062a\u0627\u0630\u060c \u0642\u0633\u0645 \u0639\u0644\u0645 \u0627\u0644\u0646\u0641\u0633 \u0641\u064a\u00a0\u062c\u0627\u0645\u0639\u0629 \u0648\u0627\u0634\u0646\u0637\u0646<\/span><\/a>,\u00a0\u0633\u064a\u0627\u062a\u0644<\/span>, commented, “The paper provides a comprehensive comparison of the performance of MCO with other opsins in development for treating retinal degenerative diseases. As such, it provides critical insights to support computational modeling for predicting sight recovery in patients treated with MCO and other opsins.”<\/p>\n

\u0627\u0646\u0642\u0631 \u0647\u0646\u0627 \u0644\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0627\u0644\u0648\u0631\u0642\u0629 \u0627\u0644\u0628\u062d\u062b\u064a\u0629 \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629.<\/a><\/p>\n

\u062d\u0648\u0644 \u0634\u0631\u0643\u0629 \u0646\u0627\u0646\u0648\u0633\u0643\u0648\u0628 \u062b\u064a\u0631\u0627\u0628\u064a\u0648\u062a\u064a\u0643\u0633 \u0625\u0646\u0643.
<\/b>\u062a\u064f\u0637\u0648\u0651\u0631 \u0634\u0631\u0643\u0629 Nanoscope Therapeutics \u0639\u0644\u0627\u062c\u064b\u0627 \u0628\u0635\u0631\u064a\u064b\u0627 \u0648\u0631\u0627\u062b\u064a\u064b\u0627 \u0645\u064f\u0633\u062a\u0639\u0627\u062f\u064b\u0627 \u0644\u0644\u0628\u0635\u0631\u060c \u0644\u0627 \u064a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u062c\u064a\u0646\u0627\u062a\u060c \u0644\u0645\u0644\u0627\u064a\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0641\u0642\u062f\u0648\u0627 \u0628\u0635\u0631\u0647\u0645 \u0628\u0633\u0628\u0628 \u0623\u0645\u0631\u0627\u0636 \u062a\u0646\u0643\u0633 \u0627\u0644\u0634\u0628\u0643\u064a\u0629. \u0648\u064a\u0623\u062a\u064a \u0647\u0630\u0627 \u0628\u0639\u062f \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0627\u0644\u062a\u064a \u062d\u0642\u0642\u062a\u0647\u0627 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 (\u0628) \u0645\u0646 \u062a\u062c\u0631\u0628\u0629 RESTORE \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0645\u0631\u0627\u0643\u0632\u060c \u0648\u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a\u0629\u060c \u0648\u0627\u0644\u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629\u060c \u0648\u0627\u0644\u0645\u0636\u0628\u0648\u0637\u0629 \u0628\u0627\u0644\u063a\u0641\u0644\u060c \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0635\u0628\u0627\u063a\u064a. (NCT04945772)<\/a>, \u0623\u0639\u0644\u0646\u062a \u0627\u0644\u0634\u0631\u0643\u0629 \u0639\u0646 \u062e\u0637\u062a\u0647\u0627 \u0644\u0628\u062f\u0621\u00a0\u062a\u0642\u062f\u064a\u0645 \u0637\u0644\u0628 \u062a\u0631\u062e\u064a\u0635 BLA \u0644\u0640 MCO-010 \u0644\u0639\u0644\u0627\u062c RP<\/a>. \u0641\u064a \u062d\u0627\u0644 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u064a\u0647\u060c \u064a\u0645\u062a\u0644\u0643 \u0639\u0642\u0627\u0631 MCO-010 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0623\u0646 \u064a\u0635\u0628\u062d \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0642\u064a\u0627\u0633\u064a \u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0635\u0628\u0627\u063a\u064a\u060c \u062d\u064a\u062b \u064a\u064f\u0639\u0637\u0649 \u0643\u062d\u0642\u0646\u0629 \u0648\u0627\u062d\u062f\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u0632\u062c\u0627\u062c\u064a \u0641\u064a \u0627\u0644\u0639\u064a\u0627\u062f\u0629 \u062f\u0648\u0646 \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u062c\u064a\u0646\u064a\u0629. \u0648\u0642\u062f \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0634\u0631\u0643\u0629 \u0623\u064a\u0636\u064b\u0627 \u0646\u062a\u0627\u0626\u062c \u0648\u0627\u0639\u062f\u0629 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 STARLIGHT \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636 \u0633\u062a\u0627\u0631\u063a\u0627\u0631\u062f\u062a (SD) \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u0642\u0627\u0631 MCO-010. (NCT05417126)<\/a> \u0648\u064a\u062e\u0637\u0637 \u0644\u0628\u062f\u0621\u00a0\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u062a\u0633\u062c\u064a\u0644\u064a\u0629<\/a>\u00a0\u0641\u064a \u0639\u0627\u0645 2025. \u062d\u0635\u0644 MCO-010 \u0639\u0644\u0649 \u062a\u0635\u0646\u064a\u0641\u0627\u062a \u0627\u0644\u0645\u0633\u0627\u0631 \u0627\u0644\u0633\u0631\u064a\u0639 \u0645\u0646 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0648\u062a\u0635\u0646\u064a\u0641\u0627\u062a \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u064a\u062a\u064a\u0645\u0629 \u0644\u0643\u0644 \u0645\u0646 RP \u0648SD. \u062a\u0634\u0645\u0644 \u0627\u0644\u0628\u0631\u0627\u0645\u062c \u0645\u0627 \u0642\u0628\u0644 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0639\u0645\u0649 \u0627\u0644\u062e\u0644\u0642\u064a \u0644\u0644\u064a\u0628\u0631 (LCA)\u060c \u0641\u064a \u062f\u0631\u0627\u0633\u0627\u062a \u062a\u0645\u0643\u064a\u0646 IND\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0623\u0635\u0644 \u062c\u0627\u0647\u0632 \u0644\u0640 IND \u0644\u0644\u0636\u0645\u0648\u0631 \u0627\u0644\u062c\u063a\u0631\u0627\u0641\u064a (GA).<\/p>\n

\u0627\u0644\u0627\u062a\u0635\u0627\u0644 \u0628\u0627\u0644\u0645\u0633\u062a\u062b\u0645\u0631:<\/b>
\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648\u0633\u0643\u0648\u0628
(817) 857-1186
PR@nanostherapeutics.com<\/a><\/p>\n

\u0627\u0644\u0645\u0635\u062f\u0631 \u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

New research paper highlights the unique structure and function of Nanoscope’s synthetic opsin, supporting its potential in vision restoration DALLAS,\u00a0July 22, 2025\u00a0—\u00a0Nanoscope Therapeutics Inc., a biotechnology company committed to developing and commercializing novel gene therapies for patients suffering vision loss from retinal degenerative diseases, today announced the publication of a paper\u00a0“Topology and Mechanism of Broadband […]<\/p>\n","protected":false},"author":6,"featured_media":9217,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13,8],"tags":[],"class_list":["post-9216","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-home-page","category-nanoscope-press-release"],"yoast_head":"\nNanoscope Therapeutics Publishes Mechanism of Action Details for Proprietary Broadband and Fast Multi-Characteristic Opsin Technology - Nanoscope Therapeutics<\/title>\n<meta name=\"description\" content=\"Our multi-characteristic opsin (MCO) platform is the first to demonstrate an ability to restore vision to retinal disease patients with severe vision loss in clincial trials. Nanoscope has developed MCO-010, the first and only broad spectrum, fast response and ultra-sensitive optogenetic technology for vision restoration that is gene-agnostic.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nanostherapeutics.com\/ar\/2025\/07\/22\/nanoscope-therapeutics-publishes-mechanism-of-action-details-for-proprietary-broadband-and-fast-multi-characteristic-opsin-technology\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nanoscope Therapeutics Publishes Mechanism of Action Details for Proprietary Broadband and Fast Multi-Characteristic Opsin Technology - Nanoscope Therapeutics\" \/>\n<meta property=\"og:description\" content=\"Our multi-characteristic opsin (MCO) platform is the first to demonstrate an ability to restore vision to retinal disease patients with severe vision loss in clincial trials. 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