{"id":5846,"date":"2024-10-21T15:48:25","date_gmt":"2024-10-21T20:48:25","guid":{"rendered":"https:\/\/nanostherapeutics.com\/?p=5846"},"modified":"2025-06-27T08:34:07","modified_gmt":"2025-06-27T13:34:07","slug":"nanoscope-publishes-breakthrough-showing-mco-010-treatment-arrests-neurodegeneration","status":"publish","type":"post","link":"https:\/\/nanostherapeutics.com\/ja\/2024\/10\/21\/nanoscope-publishes-breakthrough-showing-mco-010-treatment-arrests-neurodegeneration\/","title":{"rendered":"\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u3001MCO-010\u6cbb\u7642\u304c\u795e\u7d4c\u5909\u6027\u3092\u6291\u5236\u3059\u308b\u3068\u3044\u3046\u753b\u671f\u7684\u306a\u7814\u7a76\u3092\u767a\u8868"},"content":{"rendered":"
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\u30c0\u30e9\u30b9<\/span><\/span>,\u00a02024\u5e7410\u670821\u65e5<\/span><\/span>\u00a0 \u2014 \u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u682a\u5f0f\u4f1a\u793e<\/a>\u7db2\u819c\u5909\u6027\u75be\u60a3\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\u3092\u958b\u767a\u3057\u3066\u3044\u308b\u5f8c\u671f\u81e8\u5e8a\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u3067\u3042\u308b\u306f\u3001\u672c\u65e5\u3001\u00a0\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u30d3\u30b8\u30e7\u30f3\u79d1\u5b66\u6280\u8853\u306b\u304a\u3051\u308b\u753b\u671f\u7684\u306a\u767a\u898b<\/a>\u00a0(TVST\u3001ARVO \u30b8\u30e3\u30fc\u30ca\u30eb) \u5149\u5e72\u6e09\u65ad\u5c64\u64ae\u5f71\u6cd5\u3068\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u5206\u6790\u306b\u3088\u3063\u3066\u8a55\u4fa1\u3057\u305f\u3068\u3053\u308d\u3001\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7 (RP) \u306e\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u5185\u7db2\u819c\u306e MCO-010 \u5149\u907a\u4f1d\u5b66\u7684\u6cbb\u7642\u304c\u3055\u3089\u306a\u308b\u7db2\u819c\u5909\u6027\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

MCO-010\u785d\u5b50\u4f53\u5185\u6295\u4e0e\u5f8c\uff08\u30bd\u30f3\u30d4\u30ec\u30c1\u30b2\u30cd\u30fb\u30a4\u30b9\u30c6\u30d1\u30eb\u30dc\u30d9\u30af<\/i>)\u3001\u7d04 80% \u306e\u53cc\u6975\u7d30\u80de\u304c\u7db2\u819c\u306b\u5c0e\u5165\u3055\u308c\u3001\u5bfe\u7167\u7fa4\u3068\u306f\u7570\u306a\u308a\u3001\u7db2\u819c\u306e\u539a\u3055\u306e\u5909\u5316\u306f\u89b3\u5bdf\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u306e\u8ad6\u6587\u3067\u8aac\u660e\u3055\u308c\u3066\u3044\u308b\u7d50\u679c\u306f\u3001\u5149\u53d7\u5bb9\u4f53\u5909\u6027\u3092\u8d77\u3053\u3057\u3066\u3044\u308b\u30de\u30a6\u30b9\u306e\u7db2\u819c\u306b\u304a\u3051\u308b MCO-010 \u306e\u767a\u73fe\u304c\u3001\u3055\u3089\u306a\u308b\u55aa\u5931\u3092\u6b62\u3081\u3001\u7db2\u819c\u7d30\u80de\u5c64\u306e\u3055\u3089\u306a\u308b\u6df7\u4e71\u3092\u9632\u3050\u3068\u3044\u3046\u8a3c\u62e0\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u201c\u300cMCO-010\u306f\u3001\u73fe\u5728\u81e8\u5e8a\u8a66\u9a13\u4e2d\u306e\u552f\u4e00\u306e\u5e83\u5e2f\u57df\u3067\u9ad8\u901f\u304b\u3064\u9ad8\u611f\u5ea6\u306a\u30aa\u30d7\u30b7\u30f3\u3067\u3042\u308a\u3001\u9032\u884c\u3057\u305f\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\u60a3\u8005\u306e\u8996\u529b\u306e\u5927\u5e45\u306a\u6539\u5584\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u884c\u52d5\u5b66\u7684\u304a\u3088\u3073\u96fb\u6c17\u751f\u7406\u5b66\u7684\u30a2\u30c3\u30bb\u30a4\u3067\u6e2c\u5b9a\u3055\u308c\u305fMCO-010\u785d\u5b50\u4f53\u5185\u6ce8\u5c04\u306b\u3088\u308b\u8996\u529b\u56de\u5fa9\u306b\u52a0\u3048\u3066\u3001MCO-010\u306e\u3053\u306e\u75be\u60a3\u4fee\u98fe\u4f5c\u7528\u306f\u3001\u7db2\u819c\u5185\u5c64\u306e\u53cc\u6975\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u5149\u907a\u4f1d\u5b66\u7642\u6cd5\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u6cbb\u7642\u4e0a\u306e\u5229\u70b9\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u300d\u3068\u535a\u58eb\u306f\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002.\u00a0\u30f4\u30a3\u30cb\u30c3\u30c8\u30fb\u30de\u30cf\u30b8\u30e3\u30f3<\/span>\u3001\u773c\u79d1\u6559\u6388\u517c\u7814\u7a76\u526f\u59d4\u54e1\u9577\u00a0\u30b9\u30bf\u30f3\u30d5\u30a9\u30fc\u30c9\u5927\u5b66<\/span>.<\/p>\n

\u201c\u300cMCO-010\u306e\u3053\u306e\u75be\u60a3\u4fee\u98fe\u4f5c\u7528\u306f\u3001\u30b9\u30bf\u30fc\u30ac\u30eb\u30c8\u75c5\u306e\u52d5\u7269\u30e2\u30c7\u30eb\u3084\u5730\u7406\u7684\u840e\u7e2e\u75c7\u306e\u975e\u30d2\u30c8\u970a\u9577\u985e\u30e2\u30c7\u30eb\u3067\u3082\u89b3\u5bdf\u3055\u308c\u3066\u3044\u308b\u300d\u3068\u8ff0\u3079\u305f\u3002\u00a0\u30b5\u30de\u30ec\u30f3\u30c9\u30e9\u30fb\u30e2\u30cf\u30f3\u30c6\u30a3<\/span>, \u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u793e\u306e\u793e\u9577\u517c\u6700\u9ad8\u79d1\u5b66\u8cac\u4efb\u8005\u3067\u3042\u308b\u535a\u58eb\u306f\u3001\u300c\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\u306e\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u7db2\u819c\u69cb\u9020\u306e\u5b89\u5b9a\u5316\u3092\u793a\u3059\u4e88\u5099\u7684\u306a\u8a3c\u62e0\u304c\u5f97\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u89e3\u5256\u5b66\u7684\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u9577\u671f\u7684\u306a\u8a55\u4fa1\u3092\u5b9f\u65bd\u3059\u308b\u4e88\u5b9a\u3067\u3059\u300d\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u201c<\/p>\n

\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e\u306b\u3064\u3044\u3066
<\/b>\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u306f\u3001\u6cbb\u7642\u6cd5\u306e\u306a\u3044\u7db2\u819c\u5909\u6027\u75be\u60a3\u3067\u5931\u660e\u3057\u305f\u4f55\u767e\u4e07\u4eba\u3082\u306e\u60a3\u8005\u306e\u305f\u3081\u306b\u3001\u907a\u4f1d\u5b50\u306b\u4f9d\u5b58\u3057\u306a\u3044\u8996\u529b\u56de\u5fa9\u306e\u305f\u3081\u306e\u30aa\u30d7\u30c8\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u7642\u6cd5\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\u3002\u7db2\u819c\u5909\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308bRESTORE\u30d5\u30a7\u30fc\u30ba2b\u591a\u65bd\u8a2d\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u507d\u5bfe\u7167\u81e8\u5e8a\u8a66\u9a13\u306e\u826f\u597d\u306a\u8a66\u9a13\u7d42\u4e86\u7d50\u679c\u3092\u53d7\u3051\u3066\uff08NCT04945772<\/a>\uff09\u3001 \u4f1a\u793e\u00a0BLA\u7533\u8acb\u3092\u958b\u59cb\u3059\u308b\u8a08\u753b\u3092\u767a\u8868\u3057\u305f<\/a>\u00a0\u540c\u793e\u306f\u3001RP\u6cbb\u7642\u85ac\u3068\u3057\u3066MCO-010\u30922025\u5e74\u7b2c1\u56db\u534a\u671f\u306b\u958b\u767a\u3059\u308b\u4e88\u5b9a\u3067\u3042\u308b\u3002MCO-010\u306f\u3001RP\u3068Stargardt\u306e\u4e21\u65b9\u3067FDA\u306e\u30d5\u30a1\u30b9\u30c8\u30c8\u30e9\u30c3\u30af\u6307\u5b9a\u3068FDA\u306e\u5e0c\u5c11\u75be\u75c5\u7528\u533b\u85ac\u54c1\u6307\u5b9a\u3092\u53d7\u3051\u3066\u3044\u308b\u3002\u540c\u793e\u306f\u3001Stargardt\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fMCO-010\u7642\u6cd5\u306e\u7b2c2\u76f8STARLIGHT\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u3066\u3044\u308b\uff08NCT05417126<\/a>\uff09\u305d\u3057\u3066\u6700\u8fd1\u00a0\u7b2c3\u30d5\u30a7\u30fc\u30ba\u3092\u958b\u59cb\u3059\u308b\u8a08\u753b\u3092\u767a\u8868\u3057\u305f<\/a>\u00a02025\u5e74\u7b2c1\u56db\u534a\u671f\u306b\u767b\u9332\u8a66\u9a13\u3092\u5b9f\u65bd\u3002\u524d\u81e8\u5e8a\u8cc7\u7523\u306b\u306f\u3001\u5730\u56f3\u72b6\u840e\u7e2e\u306b\u5bfe\u3059\u308b\u975e\u30a6\u30a4\u30eb\u30b9\u6027\u30ec\u30fc\u30b6\u30fc\u9001\u9054MCO-020\u907a\u4f1d\u5b50\u6cbb\u7642\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n

\u6295\u8cc7\u5bb6\u9023\u7d61\u5148:<\/b>
\u30a2\u30eb\u30b4\u30c3\u30c8\u30d1\u30fc\u30c8\u30ca\u30fc\u30ba
(212) 600-1902
PR@nanostherapeutics.com<\/a><\/p>\n

\u51fa\u5178 \u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9<\/p>\n<\/div>\n<\/div>\n<\/section>\n<\/article>","protected":false},"excerpt":{"rendered":"

DALLAS,\u00a0Oct. 21, 2024\u00a0 \u2014 Nanoscope Therapeutics Inc., a late-stage clinical biotechnology company developing gene therapies for retinal degenerative diseases today announced a\u00a0breakthrough discovery in Translational Vision Science & Technology\u00a0(TVST, an ARVO journal) demonstrating that MCO-010 optogenetic treatment of the inner retina arrests further retinal degeneration in an animal model of retinitis pigmentosa (RP), as assessed by optical coherence tomography and immunohistochemical analysis. Following intravitreal MCO-010 treatment (sonpiretigene isteparvovec), approximately 80% of bipolar cells were transduced in the retina, and no alterations in retinal thickness were observed, unlike the control group. The results described in the publication provide evidence that the expression of MCO-010 in the retinas of mice experiencing photoreceptor […]<\/p>\n","protected":false},"author":6,"featured_media":5847,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13,8],"tags":[],"class_list":["post-5846","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-home-page","category-nanoscope-press-release"],"yoast_head":"\nNanoscope Publishes Breakthrough Showing MCO-010 Treatment Arrests Neurodegeneration - Nanoscope Therapeutics<\/title>\n<meta name=\"description\" content=\"Our multi-characteristic opsin (MCO) platform is the first to demonstrate an ability to restore vision to retinal disease patients with severe vision loss in clincial trials. 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