{"id":9246,"date":"2025-07-28T07:20:48","date_gmt":"2025-07-28T12:20:48","guid":{"rendered":"https:\/\/nanostherapeutics.com\/?p=9246"},"modified":"2025-07-28T07:26:51","modified_gmt":"2025-07-28T12:26:51","slug":"nanoscope-therapeutics-data-to-be-presented-at-2025-american-society-of-retina-specialists-annual-scientific-meeting","status":"publish","type":"post","link":"https:\/\/nanostherapeutics.com\/ja\/2025\/07\/28\/nanoscope-therapeutics-data-to-be-presented-at-2025-american-society-of-retina-specialists-annual-scientific-meeting\/","title":{"rendered":"\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e\u306e\u30c7\u30fc\u30bf\u304c\u30012025\u5e74\u7c73\u56fd\u7db2\u819c\u5c02\u9580\u533b\u5354\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a\u3067\u767a\u8868\u3055\u308c\u308b\u4e88\u5b9a\u3067\u3059\u3002"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"9246\" class=\"elementor elementor-9246\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6d5ad04f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6d5ad04f\" data-element_type=\"section\" data-e-type=\"section\">\r\n\t\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\r\n\t\t\t\t\r\n\t\t\t\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5bf9bdef\" data-id=\"5bf9bdef\" data-element_type=\"column\" data-e-type=\"column\">\r\n\r\n\t\t\t\t\r\n\t\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\r\n\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e3a8c93 elementor-widget elementor-widget-text-editor\" data-id=\"e3a8c93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3 class=\"prntac\" style=\"text-align: center;\"><i>RESTORE\u8ffd\u8de1\u8abf\u67fb\uff08REMAIN\uff09\u306e126\u9031\u9593\u306e\u7d50\u679c\u306f\u3001\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\u306b\u5bfe\u3059\u308bNanoscope\u793e\u306eMCO-010\u5149\u907a\u4f1d\u5b66\u7642\u6cd5\u306e\u9577\u671f\u7684\u306a\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u5f37\u8abf\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/i><\/h3><p><span class=\"legendSpanClass\"><span class=\"xn-location\">\u30c0\u30e9\u30b9<\/span><\/span>,\u00a0<span class=\"legendSpanClass\"><span class=\"xn-chron\">2025\u5e747\u670828\u65e5<\/span><\/span>\u00a0\/PRNewswire\/ \u2014\u00a0<a href=\"http:\/\/nanostherapeutics.com\/ja\/\" target=\"_blank\" rel=\"nofollow noopener\">\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e,<\/a>\u00a0\u7db2\u819c\u5909\u6027\u75be\u60a3\u306b\u3088\u308b\u91cd\u5ea6\u306e\u8996\u529b\u55aa\u5931\u306b\u82e6\u3057\u3080\u60a3\u8005\u306e\u305f\u3081\u306e\u3001\u907a\u4f1d\u5b50\u306b\u4f9d\u5b58\u3057\u306a\u3044\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3068\u5546\u696d\u5316\u306b\u53d6\u308a\u7d44\u3080\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u306f\u3001\u540c\u793e\u306e\u591a\u7279\u6027\u30aa\u30d7\u30b7\u30f3\uff08MCO\uff09\u907a\u4f1d\u5b50\u6cbb\u7642\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u304c\u3001\u535a\u58eb\u306b\u3088\u308b\u30d7\u30ec\u30bc\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3\u3067\u7d39\u4ecb\u3055\u308c\u308b\u3053\u3068\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002.\u00a0<span class=\"xn-person\">\u30c7\u30d3\u30c3\u30c9\u30fbS\u30fb\u30ea\u30e3\u30aa<\/span>\u00a0\u3067\u00a0<a href=\"https:\/\/www.asrs.org\/annual-meeting\" target=\"_blank\" rel=\"nofollow noopener\">2025\u5e74\u7c73\u56fd\u7db2\u819c\u5c02\u9580\u533b\u5354\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a<\/a>\u3001\u958b\u50ac\u4e2d\u00a0<span class=\"xn-chron\">2025\u5e747\u670830\u65e5\uff5e8\u67082\u65e5<\/span>\u00a0\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5dde\u30ed\u30f3\u30b0\u30d3\u30fc\u30c1\u306e\u30ed\u30f3\u30b0\u30d3\u30fc\u30c1\u30fb\u30b3\u30f3\u30d9\u30f3\u30b7\u30e7\u30f3\u30bb\u30f3\u30bf\u30fc\u306b\u3066\u3002.<\/p><p>\u30ea\u30e3\u30aa\u535a\u58eb\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u5fc5\u8981\u3068\u305b\u305a\u3001\u8a3a\u7642\u6240\u30671\u56de\u785d\u5b50\u4f53\u5185\u6ce8\u5c04\u3092\u884c\u3046\u3060\u3051\u3067\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\uff08RP\uff09\u60a3\u8005\u3092\u6cbb\u7642\u3059\u308bMCO-010\u306e\u3001\u9ad8\u3044\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u95a2\u3059\u308b126\u9031\u9593\u306e\u30c7\u30fc\u30bf\u3092\u767a\u8868\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002.\u00a0<a href=\"https:\/\/nanostherapeutics.com\/ja\/2025\/07\/14\/nanoscope-therapeutics-initiates-rolling-submission-of-biologics-license-application-to-fda-for-mco-010-the-first-gene-agnostic-therapy-to-treat-retinitis-pigmentosa\/\" target=\"_blank\" rel=\"nofollow noopener\">\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u793e\u306f\u6700\u8fd1\u3001\u751f\u7269\u88fd\u5264\u627f\u8a8d\u7533\u8acb\u306e\u30ed\u30fc\u30ea\u30f3\u30b0\u7533\u8acb\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002<\/a>\u00a0\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u793e\u306f\u3001\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\uff08RP\uff09\u306b\u3088\u308b\u91cd\u5ea6\u306e\u8996\u529b\u55aa\u5931\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3001MCO-010\u306e\u751f\u7269\u88fd\u5264\u627f\u8a8d\u7533\u8acb\uff08BLA\uff09\u3092FDA\u306b\u63d0\u51fa\u3057\u307e\u3057\u305f\u3002\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u793e\u306eRESTORE\u8ffd\u8de1\u8abf\u67fb\uff08REMAIN\uff09\u306e\u30c7\u30fc\u30bf\u306f\u3001\u540c\u793e\u306eBLA\u30ed\u30fc\u30ea\u30f3\u30b0\u7533\u8acb\u306e\u57fa\u76e4\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002.<\/p><p>\u30d7\u30ec\u30bc\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3\u306e\u8a73\u7d30\u306f\u4ee5\u4e0b\u306e\u3068\u304a\u308a\u3067\u3059\u3002<\/p><div><div class=\"divOverflow\"><div class=\"table-responsive\"><table class=\"prnbcc\" border=\"0\" width=\"\" cellspacing=\"0\" cellpadding=\"1\"><tbody><tr><td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" width=\"\" height=\"\"><p class=\"prnews_p dnr\"><span class=\"prnews_span\"><b>\u30bf\u30a4\u30c8\u30eb\uff1a<\/b>\u00a0 \u00a0 \u00a0<\/span><\/p><\/td><td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" width=\"\" height=\"\"><p class=\"prnews_p dnr\"><span class=\"prnews_span\">\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\u306b\u5bfe\u3059\u308bMCO-010\u5149\u907a\u4f1d\u5b66\u7642\u6cd5\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u306e\u9577\u671f\u8a55\u4fa1\uff1aRESTORE\u8ffd\u8de1\u8abf\u67fb\uff08REMAIN\uff09\u306e126\u9031\u9593\u306e\u7d50\u679c<\/span><\/p><\/td><\/tr><tr><td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" width=\"\" height=\"\"><p class=\"prnews_p dnr\"><span class=\"prnews_span\"><b>\u30bb\u30c3\u30b7\u30e7\u30f3\u30bf\u30a4\u30c8\u30eb<\/b>:\u00a0<\/span><\/p><\/td><td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" width=\"\" height=\"\"><p class=\"prnews_p dnr\"><span class=\"prnews_span\">\u907a\u4f1d\u6027\u7db2\u819c\u75be\u60a3\u3068\u907a\u4f1d\u5b66\u30b7\u30f3\u30dd\u30b8\u30a6\u30e01<\/span><\/p><\/td><\/tr><tr><td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" width=\"\" height=\"\"><p class=\"prnews_p dnr\"><span class=\"prnews_span\"><b>\u30bb\u30c3\u30b7\u30e7\u30f3\u65e5:<\/b><\/span><\/p><\/td><td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" width=\"\" height=\"\"><p class=\"prnews_p dnr\"><span class=\"prnews_span\">8\u67081\u65e5\uff08\u91d1\uff09<\/span><\/p><\/td><\/tr><tr><td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" width=\"\" height=\"\"><p class=\"prnews_p dnr\"><span class=\"prnews_span\"><b>\u30bb\u30c3\u30b7\u30e7\u30f3\u6642\u9593:<\/b><\/span><\/p><\/td><td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" width=\"\" height=\"\"><p class=\"prnews_p dnr\"><span class=\"prnews_span\">\u5348\u5f8c4\u664250\u5206\u304b\u3089\u5348\u5f8c4\u664253\u5206\uff08\u592a\u5e73\u6d0b\u590f\u6642\u9593\uff09<\/span><\/p><\/td><\/tr><tr><td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" width=\"\" height=\"\"><p class=\"prnews_p dnr\"><span class=\"prnews_span\"><b>\u30d7\u30ec\u30bc\u30f3\u30bf\u30fc\uff1a<\/b>\u00a0<\/span><\/p><\/td><td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" width=\"\" height=\"\"><p class=\"prnews_p dnr\"><span class=\"prnews_span\"><a class=\"prnews_a\" href=\"https:\/\/laretina.com\/our-physicians\/david-s-liao-m-d\/\" target=\"_blank\" rel=\"nofollow noopener\">\u30c7\u30d3\u30c3\u30c9\u30fbS\u30fb\u30ea\u30e3\u30aa\u533b\u5e2b\uff08\u533b\u5b66\u535a\u58eb\u3001\u7db2\u819c\u785d\u5b50\u4f53\u75be\u60a3\u5c02\u9580\u533b\u3001\u7db2\u819c\u785d\u5b50\u4f53\u30a2\u30bd\u30b7\u30a8\u30a4\u30c4\u533b\u7642\u30b0\u30eb\u30fc\u30d7\uff09<\/a><\/span><\/p><\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><p>\u201c\u300c\u7279\u306b\u6700\u8fd1\u306eBLA\u767a\u8868\u3092\u53d7\u3051\u3066\u3001ASRS\u3067\u3053\u306e126\u9031\u9593\u306e\u30c7\u30fc\u30bf\u3092\u767a\u8868\u3067\u304d\u308b\u3053\u3068\u3092\u5b09\u3057\u304f\u601d\u3044\u307e\u3059\u300d\u3068\u8ff0\u3079\u305f\u3002\u00a0<a href=\"https:\/\/nanostherapeutics.com\/ja\/who-we-are\/sam-barone\/\" target=\"_blank\" rel=\"nofollow noopener\">\u535a\u58eb\u3002\u00a0<span class=\"xn-person\">\u30b5\u30df\u30e5\u30a8\u30eb\u30fb\u30d0\u30ed\u30fc\u30cd<\/span>, \u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u793e\u306e\u6700\u9ad8\u533b\u7642\u8cac\u4efb\u8005\u3002.<\/a>\u00a0 \u201c\u300c\u3053\u308c\u306fASRS\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u306b\u3068\u3063\u3066\u3001\u79c1\u305f\u3061\u306e\u30c7\u30fc\u30bf\u3068\u305d\u308c\u304c\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\u60a3\u8005\u306b\u53ca\u307c\u3059\u6f5c\u5728\u7684\u306a\u5f71\u97ff\u306b\u3064\u3044\u3066\u8b70\u8ad6\u3059\u308b\u7d76\u597d\u306e\u6a5f\u4f1a\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u300d\u201d<\/p><p>MCO-010\u304a\u3088\u3073Nanoscope Therapeutics\u306b\u95a2\u3059\u308b\u8a73\u7d30\u306b\u3064\u3044\u3066\u306f\u3001\u4ee5\u4e0b\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002\u00a0<a href=\"https:\/\/nanostherapeutics.com\/ja\/\" target=\"_blank\" rel=\"nofollow noopener\">www.nanostherapeutics.com<\/a>.<\/p><p><b>\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u306b\u3064\u3044\u3066<br class=\"dnr\" \/><\/b>\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e\u306f\u3001\u7db2\u819c\u5909\u6027\u75be\u60a3\u3067\u5931\u660e\u3057\u305f\u6570\u767e\u4e07\u4eba\u306e\u60a3\u8005\u306e\u305f\u3081\u306b\u3001\u907a\u4f1d\u5b50\u306b\u4f9d\u5b58\u3057\u306a\u3044\u8996\u529b\u56de\u5fa9\u306e\u305f\u3081\u306e\u5149\u907a\u4f1d\u5b66\u7684\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3057\u3066\u3044\u308b\u3002RESTORE\u30d5\u30a7\u30fc\u30ba\u3067\u306e\u826f\u597d\u306a\u7d50\u679c\u3092\u53d7\u3051\u3066\u3001\u00a0<span class=\"xn-money\">2b<\/span>\u00a0\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\uff08RP\uff09\u306b\u5bfe\u3059\u308b\u591a\u65bd\u8a2d\u5171\u540c\u3001\u7121\u4f5c\u70ba\u5316\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u81e8\u5e8a\u8a66\u9a13\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04945772\" target=\"_blank\" rel=\"nofollow noopener\">NCT04945772<\/a>\uff09\u3001FDA\u3078\u306eBLA\u7533\u8acb\u304c\u9806\u6b21\u958b\u59cb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u627f\u8a8d\u3055\u308c\u308c\u3070\u3001MCO-010\u306f\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u5fc5\u8981\u3068\u305b\u305a\u3001\u8a3a\u7642\u6240\u30671\u56de\u6ce8\u5c04\u3059\u308b\u3060\u3051\u3067\u6295\u4e0e\u3067\u304d\u308b\u305f\u3081\u3001RP\u60a3\u8005\u306e\u6a19\u6e96\u6cbb\u7642\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u540c\u793e\u306f\u307e\u305f\u3001\u30b9\u30bf\u30fc\u30ac\u30eb\u30c8\u75c5\uff08SD\uff09\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05417126\" target=\"_blank\" rel=\"nofollow noopener\">NCT05417126<\/a>\uff09\u3092\u958b\u59cb\u3057\u3001\u00a0<a href=\"https:\/\/nanostherapeutics.com\/ja\/2024\/09\/12\/nanoscope-therapeutics-announces-end-of-phase-2-meeting-with-u-s-fda-and-plan-to-initiate-a-phase-3-clinical-trial-of-mco-010-to-treat-stargardt-macular-degeneration\/\" target=\"_blank\" rel=\"nofollow noopener\">\u30d5\u30a7\u30fc\u30ba3\u767b\u9332\u8a66\u9a13<\/a>\u00a02025\u5e74\u306b\u767a\u58f2\u4e88\u5b9a\u306eMCO-010\u306f\u3001\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\uff08RP\uff09\u3068\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c7\uff08SD\uff09\u306e\u4e21\u65b9\u3067FDA\u306e\u30d5\u30a1\u30b9\u30c8\u30c8\u30e9\u30c3\u30af\u6307\u5b9a\u3068\u5e0c\u5c11\u75be\u75c5\u7528\u533b\u85ac\u54c1\u6307\u5b9a\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002\u524d\u81e8\u5e8a\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u306f\u3001IND\u7533\u8acb\u306b\u5411\u3051\u305f\u7814\u7a76\u6bb5\u968e\u306b\u3042\u308b\u30ec\u30fc\u30d0\u30fc\u5148\u5929\u6027\u9ed2\u5185\u969c\uff08LCA\uff09\u306e\u307b\u304b\u3001\u5730\u56f3\u72b6\u840e\u7e2e\u75c7\uff08GA\uff09\u306b\u5bfe\u3059\u308bIND\u7533\u8acb\u6e96\u5099\u6bb5\u968e\u306e\u85ac\u5264\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002.<\/p><p><b>\u63a5\u89e6\uff1a<br class=\"dnr\" \/><\/b>\u30ca\u30ce\u30b9\u30b3\u30fc\u30d7\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9<br class=\"dnr\" \/>(817) 857-1186<br class=\"dnr\" \/><a href=\"mailto:PR@nanostherapeutics.com\" target=\"_blank\" rel=\"nofollow noopener\">PR@nanostherapeutics.com<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t<\/section>\r\n\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>126-week results from RESTORE follow-up study (REMAIN) to highlight the extended efficacy and safety of Nanoscope\u2019s MCO-010 optogenetic therapy for Retinitis Pigmentosa DALLAS,\u00a0July 28, 2025\u00a0\/PRNewswire\/ \u2014\u00a0Nanoscope Therapeutics Inc.,\u00a0a biotechnology company committed to developing and commercializing novel gene-agnostic therapies for patients suffering severe vision loss from retinal degenerative diseases, announced that its multi-characteristic opsin (MCO) gene therapy platform will be featured in a presentation by Dr.\u00a0David S. Liao\u00a0at the\u00a02025 American Society of Retina Specialists Annual Scientific Meeting, taking place\u00a0July 30-August 2, 2025\u00a0at the Long Beach Convention Center in Long Beach, California. Dr. Liao will present 126-week data on the strong efficacy and safety profile of MCO-010 in treating retinitis pigmentosa (RP) [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":9247,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[13,8],"tags":[],"class_list":["post-9246","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-home-page","category-nanoscope-press-release"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nanoscope Therapeutics Data to be Presented at 2025 American Society of Retina Specialists Annual Scientific Meeting - Nanoscope Therapeutics<\/title>\n<meta name=\"description\" content=\"Our multi-characteristic opsin (MCO) platform is the first to demonstrate an ability to restore vision to retinal disease patients with severe vision loss in clincial trials. 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