Dr. Stephen H. Tsang, MD, PhD.
Stephen H. Tsang, M.D, Ph.D. is Laszlo T. Bito Professor of Ophthalmology, Pathology and Cell Biology at Columbia University Medical Center. He is an acclaimed geneticist in the care of individuals with retinal degenerations, and has been culturing embryonic stem (ES) cells since 1992 and created the first mouse model for a recessive form of retinitis pigmentosa (RP) by applying CRISPR genome engineering to ES cell technology in 1995. He successfully treated preclinical models of Pde6a, Pde6b, Mfrp, Rho, Cngb1 and autosomal recessive bestrophin retinopathies. He has expertise in designing and testing genome engineering strategies in pre-clinical models, developing patient-specific knock-in models, generating of patient cell lines and providing care to patients with a precision medicine approach. He is also leading efforts in FDA trials for gene therapies, including PDE6A, RAB geranylgeranyl transferase, RPGR, CNGB3, CNGA3 and ABCA4 retinopathies. He wrote 2 books: “Precision Medicine, CRISPR, and Genome Engineering: Moving from Association to Biology and Therapeutics.; and “Stem Cell Biology and Regenerative Medicine in Ophthalmology”, Springer Press, NY; and “Stem Cell Biology and Regenerative Medicine in Ophthalmology”, Springer Press, NY. He is an elected member of several honorary societies including the American Society for Clinical Investigation, Alcon Research Institute and American Ophthalmological Society. He is consistently named to various NIH study sections (DPVS standing member 2014-18).
