Nanoscope’s Optical Gene Therapies to be Featured at Optogenetics and Optical Manipulation 2021 Conference
Company’s President Samarendra Mohanty will co-chair the conference, which is part of the SPIE Photonics West Digital Forum
BEDFORD, Texas, March 5, 2021 /PRNewswire/ — Researchers of Nanoscope Therapeutics Inc., a clinical-stage biotechnology company developing gene therapies for treatment of retinal diseases, will make multiple scientific presentations featuring its groundbreaking research on optical gene delivery and opsin based neuromodulation therapy at the Optogenetics and Optical Manipulation 2021 virtual conference, March 6 – 11, 20201.
Nanoscope President Samarendra Mohanty, Ph.D., is serving as a co-chair of the event, which is part of SPIE Photonics West’s week long series of online conferences and industry programs. SPIE is an international society for optics and photonics dedicated to advancing light-based technologies.
“Nanoscope is on the verge of significant breakthroughs in optical gene therapies for improving quality of life in people with retinal and neurological diseases,” said Dr. Mohanty. “We are developing both viral vector and non-viral light delivery of genes to reprogram neurons and make them light-activatable, allowing therapeutic modulation.”
Nanoscope’s lead product is an optogenetic gene therapy, vMCO-010, that delivers light- sensitive Multi-Characteristics Opsin (MCO) into retinal cells to restore vision in patients with retinal degeneration. If successful, the optogenetic therapy would be the first treatment aimed at correcting these retinal diseases.
Nanoscope also is developing an alternative, non-viral light-based gene delivery method that is designed to be more targeted with less immunogenicity.
Below are the sessions highlighting Nanoscope’s optical gene therapy research. All three sessions will be available on-demand starting March 6.
Neuroprotection by optical delivery of therapeutic gene into retina
Author(s): Subrata Batabyal, Sanghoon Kim, Michael Carlson, Houssam Al-Saad, Jazlyn Gallego, Adnan Dibas, Samarendra Mohanty
Development and functional characterization of retinal dystrophy model using targeted layer-specific laser microirradiation
Author(s): Micahel Carlson, Sanghoon Kim, Subrata Batabyal, Samarendra Mohanty
Pain modulation by multi-characteristic opsin sensitization of inhibitory network of brain
Author(s): Darryl Narcisse, Robert Benkowski, Arman Fijany, Samarendra Mohanty
About Nanoscope Therapeutics Inc.
Nanoscope Therapeutics is advancing gene therapy using light-sensitive molecules for giving sight to the millions of blind individuals suffering from retinal degenerative diseases, for which no cure exists. Nanoscope utilizes an ambient light-sensitive MCO molecule to re-photosensitize the retina. The company’s pipeline includes optogenetics based retinal regeneration therapy for vision restoration in patients with retinitis pigmentosa and dry age-related macular degeneration.
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Nanoscope President to Deliver Talk on Gene Therapy for Retinal Diseases at Association for Ocular Pharmacology and Therapeutics Conference
Company’s lead product, an optogenetic gene therapy to restore vision for patients with retinitis pigmentosa, expected to enter seminal clinical trials in 2021
BEDFORD, Texas, March 3, 2021 /PRNewswire/ — Nanoscope Therapeutics Inc., a clinical-stage biotechnology company developing gene therapies for treatment of inherited retinal diseases, today announced that its President, Samarendra Mohanty, Ph.D., will participate in the Association for Ocular Pharmacology and Therapeutics (AOPT) 15th Biennial (Virtual) Meeting, March 4-7, 2021.
Dr. Mohanty will deliver a presentation titled, “Ready for the Future: Refunctionalizing, Reprogramming, Revitalizing and Regenerating Retina for Restoring Vision,” during an AOPT Special Session, Saturday, March 6, at 12 pm EST.
“Hundreds of millions individuals are suffering from vision loss due to damage to the retina and optic nerve,” said Dr. Mohanty, who also serves as Nanoscope’s Chief Scientific Officer. “We are developing gene therapies to reprogram retinal cells and make them functionally active to regain vision.”
In addition, Nanoscope will participate in a session Friday, March 5, at 1:30 pm EST, and will make a presentation titled: “Low-Vision Multi-Parameter Test (LVMPT) to Quantitatively Measure Visual Level of Low-Vision Patients.”
“The LVMPT measures functional vision which can serve as a novel key endpoint for our clinical trial on Low-Vision Patients,” said Sai Chavala, M.D., Chief Medical Officer of Nanoscope.
AOPT is a global, not-for-profit organization for scientists and individuals from all disciplines related to ocular pharmacology and its therapeutic applications. Members are from academic institutions, pharma and biotech industries, device companies, and clinics.
Nanoscope’s lead product is an optogenetic gene therapy, vMCO-010, that delivers light-sensitive Multi-Characteristic Opsin (MCO) into retinal cells to restore vision in patients with retinitis pigmentosa and Stargardt disease. Both applications have received orphan drug designation from the US-FDA. If successful, the optogenetic therapy would be the first treatment aimed at correcting these conditions.
About Nanoscope Therapeutics Inc.
Nanoscope Therapeutics, Bedford, TX, is advancing gene therapy using light-sensitive molecules for giving sight to the millions of blind individuals suffering from retinal degenerative disease, for which no cure exists. Nanoscope utilizes an ambient light-sensitive MCO molecule to re-sensitize the retina toward ambient light level. The company’s pipeline includes optogenetics based retinal regeneration therapy for vision restoration in patients with retinitis pigmentosa, Stargardt disease, and dry age-related macular degeneration (AMD).
Opus Biotech Communications
Nanoscope® team conferred Phase II Retinal Organoid Challenge (ROC) award by National Institute of Health
BEDFORD, Texas, Feb. 2, 2021 /PRNewswire/ — To meet the advance challenge for generating a physiologically relevant three-dimensional (3D) retinal organoid, Nanoscope researchers® in collaboration with University of Colorado, and Miami University were recently awarded the top prize from the 3D-ROC challenge by the National Institute of Health (NIH). https://www.nei.nih.gov/about/goals-and-accomplishments/nei-research-initiatives/3-d-retina-organoid-challenge-3-d-roc/2017-ideation-challenge/2017-ideation-winner-and-honorable-mention
The organoids provide a unique opportunity for evaluating novel gene therapies including Multi-Characteristic Opsin (MCO) gene therapy for vision restoration. This is an active therapeutic development area for Nanoscope Therapeutics to evaluate effectiveness of MCO optogenetic therapy, which has shown promise in restoring sight in blind subjects. The opsin-based (and other gene therapy) treatment requires evaluation of potency in-vitro (for release characterization of drug) and objective clinical measurements. While we are currently using fluorescence imaging for objective measurement of potency of MCO-drug, there is a need for label-free evaluation of light activated activities in opsin-sensitized neurons. This is especially important because fluorescence methods inherently perturb the light-sensitive opsin-expressing neurons.
“Nanoscope continue to develop breakthrough technologies to assess neural activities without use of excitation light (as used in fluorescence) and is currently working on implementing this approach for objective label-free detection of activities of natural photoreceptors of eye as well as opsin-sensitized cellular activities in response to light stimulation in-vivo,” said Samarendra Mohanty, PhD, President and Chief Scientific Officer.
For the 3D ROC challenge, Nanoscope used near-infrared light-based Optical Coherence Tomography (OCT) integrated with electro and opto-physiology device to measure both structure and function of layer-specific cells in the targeted regions of retina.
This label-free activity detection technology has already attracted several Biopharmaceutical companies to evaluate their therapeutic approaches.
“We are also advancing OCT guided targeted laser microirradiation technology for creating models of degenerative eye diseases such as Retinitis Pigmentosa (RP) and dry age-related macular degeneration (dry-AMD) as well as for targeted delivery of therapeutic genes,” said Sulagna Bhattacharya, CEO of Nanoscope.
About NANOSCOPE THERAPEUTICS Inc.
Nanoscope Therapeutics is advancing gene therapy using light-sensitive MCO-molecules for giving sight to the millions of blind individuals suffering from retinal degenerative disease, for which no cure exists. Our pipeline includes optogenetics based retinal regeneration therapy for vision restoration in patients with RP, Stargardt disease, and dry-AMD.
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